Gerardus Johannes Mulder
Gerardus Johannes Mulder
|Died||18 April 1880 (aged 77)|
|Alma mater||Utrecht University|
Wilhelmina van Rossem
|Children||6, including Eduard|
|Thesis||Dissertatio medica de opio ejusque principiis, actione inter se comparatis (1825)|
|Doctoral advisor||Nicolaas Cornelis de Fremery|
This article needs additional citations for verification. (February 2015)
Following a suggestion by Jöns Jacob Berzelius, Mulder used the term protein in his 1838 paper, "On the composition of some animal substances" (originally in French but translated in 1839 to German). In the same publication, he also proposed that animals draw most of their protein from plants.
Mulder "was the first to propose a theory concerning the causes of the differences between albumin, casein, and fibrin, and other substances more or less similar to them in physical properties and in their chemical behavior when exposed to reagents. Analyses of these substances showed that their percentage contribution with respect to carbon, hydrogen, nitrogen and oxygen were so similar as to suggest that they contain one common radical." This radical, a macromolecule, had formula and was known as protein. The variations in albuminous substances were attributed to peripheral bonds of protein to sulfur and/or phosphorus. Justus Liebig and his students sought to determine the structure of proteins, but until the methods of Emil Fischer and Franz Hofmeister became available, the amino acid decompositions were unknown.
- "Prof.dr. G.J. Mulder (1802–1880)". Catalogus Professorum Academiæ Rheno-Traiectinæ (in Dutch). Utrecht University. Retrieved 10 June 2021.
- Wels, C. B. (12 November 2013) [First published 1985]. "Mulder, Gerardus Johannis (1802–1880)". Biografisch Woordenboek van Nederland (in Dutch). The Hague.
- Bulletin des Sciences Physiques et Naturelles en Néerlande (1838). pg 104. SUR LA COMPOSITION DE QUELQUES SUBSTANCES ANIMALES
- Hartley, Harold (1951). "Origin of the Word 'Protein.'". Nature. 168 (4267): 244. Bibcode:1951Natur.168..244H. doi:10.1038/168244a0. PMID 14875059. S2CID 4271525.
- "Ueber die Zusammensetzung einiger thierischen Substanzen". Journal für Praktische Chemie (in German). 16: 129–152. 1838. doi:10.1002/prac.18390160137.
- Elmer McCollum (1957) A History of Nutrition, chapter 4: Knowledge of Albuminous Substances, page 48 "The studies of Mulder on albuminous substances", Houghton-Mifflin
- Hubert Bradford Vickery (1942) "Liebig and the Proteins", Journal of Chemical Education doi:10.1021/ed019p73
- Clarke, Ernest (1899). . In Lee, Sidney (ed.). Dictionary of National Biography. 58. London: Smith, Elder & Co. doi:10.1093/odnb/9780192683120.013.28345.
- Goddard, Nicholas (10 December 2020) [First published in print and online 23 September 2004]. "Voelcker, (John Christopher) Augustus". Oxford Dictionary of National Biography. Oxford University Press. doi:10.1093/ref:odnb/28345.
- Ihde, Aaron (1964) The Development of Modern Chemistry, Harper and Row, pages 359 and 423–424.
- On the composition of some animal substances Translation of parts of Mulder's article from: Mikulás Teich, A Documentary History of Biochemistry, 1770-1940 (Rutherford, NJ: Fairleigh Dickinson University Press, 1992)
"Ueber die Zusammensetzung einiger thierischen Substanzen". Journal für Praktische Chemie (in German). 16: 129–152. 1839. doi:10.1002/prac.18390160137.